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Rabbit Anti-Mouse IDE Antibody (CBMOAB-00293FYA)


Cat: CBMOAB-00293FYA
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
CloneF00293FYA
SpecificityThis antibody is binds to Mouse IDE and has cross reactivity with Human, Rat, Zebrafish.
FormatLiquid
BufferTBS, pH 7.4
PurificationPurified with Protein A affinity chromatography
Cellular LocalizationCytoplasm; Cell membrane; Secreted

Application Information

ApplicationWB, IHC
Application NotesWB: 1:1,000-1:2,000
IHC: 1:50-1:200

Target

IntroductionThis gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Product OverviewRabbit Anti-Mouse IDE (clone F00293FYA) Antibody (CBMOAB-00293FYA) is a Rabbit antibody against the IDE. It can be used for IDE detection in Western Blot, Immunohistochemistry.
Alternative NamesInsulin Degrading Enzyme
Gene ID3416
UniProt IDP14735
For Research Use Only | Not For Clinical Use.

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