Rabbit Anti-Mouse IDE Antibody (CBMOAB-00293FYA)
Cat: CBMOAB-00293FYA
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio) |
| Clone | F00293FYA |
| Specificity | This antibody binds to Mouse IDE and has cross reactivity with Human, Rat, Zebrafish. |
| Format | Liquid or Lyophilized |
| Buffer | TBS, pH 7.4 |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Purified with Protein A affinity chromatography |
| Cellular Localization | Cytoplasm; Cell membrane; Secreted |
Application Information
| Application | WB, IHC |
| Application Notes | WB: 1:1,000-1:2,000 IHC: 1:50-1:200 |
Target
| Introduction | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |
| Product Overview | Rabbit Anti-Mouse IDE (clone F00293FYA) Antibody (CBMOAB-00293FYA) is a Rabbit antibody against the IDE. It can be used for IDE detection in Western Blot, Immunohistochemistry. |
| Alternative Names | Insulin Degrading Enzyme |
| Gene ID | 3416 |
| UniProt ID | P14735 |
See other products for " IDE "
| MO-AB-13937R | Mouse Anti-Cattle IDE Antibody (MO-AB-13937R) |
| MO-DKB-03621W | Rabbit Anti-IDE (C-terminal, clone ms2109-029) Antibody (Cat MO-DKB-03621W) |
| CBMOAB-60284FYC | Mouse Anti-Rhesus IDE Antibody (CBMOAB-60284FYC) |
| MO-DKB-01481W | Rabbit Anti-IDE Antibody (MO-DKB-01481W) |
| MO-AB-31213W | Mouse Anti-Dog IDE Antibody (MO-AB-31213W) |
| MO-AB-23092W | Mouse Anti-Chimpanzee IDE Antibody (MO-AB-23092W) |
| MO-NAB-00419W | Rabbit Anti-IDE Antibody |
| MO-AB-57102W | Mouse Anti-Marmoset IDE Antibody (MO-AB-57102W) |
| CBMOAB-80244FYA | Mouse Anti-Zebrafish ide Antibody (CBMOAB-80244FYA) |
| CBMOAB-20909FYA | Mouse Anti-D. melanogaster Ide Antibody (CBMOAB-20909FYA) |
For Research Use Only | Not For Clinical Use.
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