Rabbit Anti-mmp2 Antibody (MOFY-1222-FY26)


Cat: MOFY-1222-FY26
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Specifications

Host speciesRabbit
Species ReactivityZebrafish
FormatLiquid or Lyophilized
BufferPBS, 50% glycerol
Regulatory StatusFor Research Use Only. Not For Clinical Use.
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use

Application Information

ApplicationWB, IHC, ICC, IF, ELISA

Target

IntroductionThe gene is a member of the matrix metalloproteinase (MMP) gene family, a family of zinc-dependent enzymes that cleave components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, a type IV collagenase whose catalytic site contains three type II fibronectin repeats, which binds denatured types IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur at the cell membrane. This enzyme can be activated extracellularly by proteases or intracellularly by its S-glutathionylation without proteolytic removal of the prodomain. This protein is thought to be involved in multiple pathways, including roles in the nervous system, endometrial menstrual disorders, regulation of vascularization, and metastasis. Mutations in this gene are associated with Winchester syndrome and sarcoid-arthropathy-osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [Provided by RefSeq, October 2014]
Alternative Names72 kDa gelatinase; CLG4; CLG4A72 kDa type IV collagenase; collagenase type IV-A; EC 3.4.24; EC 3.4.24.24; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase); matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP2; MMP-2; MMP-II; MONA; neutrophil gelatinase; TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase) MMP2 CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 72 kDa type IV collagenase; collagenase type IV-A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; neutrophil gelatinase
Gene ID4313
UniProt IDP08253
For Research Use Only | Not For Clinical Use.
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