Mouse Anti-Rabbit CASP3 Antibody (MO-AB-07440Y)


Cat: MO-AB-07440Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityRabbit (Oryctolagus cuniculus)
CloneMO07440Y
SpecificityThis antibody binds to Rabbit CASP3.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionInvolved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).
Product OverviewThis product is a mouse antibody against CASP3. It can be used for CASP3 detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesCaspase-3; CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32; [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]; CASP3
UniProt IDQ8MJC3
Protein RefseqThe length of the protein is 277 amino acids long. The sequence is show below: MENNETSVDAKSIKNLETQTIHGSKSMDSGKYLDNSYKMDYPEMGLCIIINNKNFHKNTGMSSRSGTDVNAANLGETFMNLKYEVRNKNDLTREEIMELMYNVSKEDHSKRSSFICVILSHGDEGVIYGTNGPIELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDSGIETDSGVDYDMACQKIPVEADFLYAYSTAPGYYSWRNSEEGSWFIQSLCAMLKEYAHKLEFMHILTRVNRKVATEFESYSLDATFHAKKQIPCIVSMLTKELYFYH.
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For Research Use Only | Not For Clinical Use.
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