Anti-Thrb Antibody (Cat MO-MMB-0587), Goat IgG


Cat: MO-MMB-0587
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Specifications

Host speciesGoat (Capra hircus)
Species ReactivityZebrafish (Danio rerio)
ImmunogenA 17-residue peptide that matches the sequence of the internal region of thrb (see accession number: NP_571415.1).
EpitopeCenter
FormatLiquid or Lyophilized
BufferTBS, pH 7.3, 0.5% BSA
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use

Application Information

ApplicationIA
Application NotesThe optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alternative NamesThyroid hormone receptor beta; thr
UniProt IDJ9JI02
For Research Use Only | Not For Clinical Use.
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