Goat Anti-THRB (Center) Antibody (Cat MO-DKB-03440W)


Cat: MO-DKB-03440W
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Specifications

Host speciesGoat (Capra hircus)
Species ReactivityZebrafish (Danio rerio)
SpecificityThis antibody is not expected to cross-react with Thra.
ImmunogenAccording to Uniprot Zebrafish NP_571415.1, a peptide with the sequence C-DIGSAPIVNAPEGNKVD corresponding to the internal region.
EpitopeCenter
FormatLiquid or Lyophilized
BufferTris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationAffinity purified

Application Information

ApplicationWB, PEP-ELISA
Application NotesWestern Blot: 2-5 ug/mL
Peptide Enzyme-Linked Immunosorbent Assay: 1:32000
The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Product OverviewThis product is a Goat antibody against the TR beta 1/NR1A2/Thyroid Hormone Receptor beta. It can be used for TR beta 1/NR1A2/Thyroid Hormone Receptor beta detection in Western Blot, PEP-Enzyme-Linked Immunosorbent Assay.
Alternative NamesThyroid hormone receptor beta; thr
UniProt IDJ9JI02
For Research Use Only | Not For Clinical Use.
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