Mouse Anti-Zebrafish cd8a Antibody (CBMOAB-69724FYA)


Cat: CBMOAB-69724FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio)
CloneMO69724FYA
SpecificityThis antibody binds to Zebrafish cd8a.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionCD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include Cd8 Deficiency, Familial and Primary Cutaneous Aggressive Epidermotropic Cd8+ T-Cell Lymphoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T-Cell Receptor and Co-stimulatory Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and coreceptor activity.
Product OverviewMouse Anti-Zebrafish cd8a Antibody is a mouse antibody against cd8a. It can be used for cd8a detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesCD8 alpha; cd8a; CD8 alph
UniProt IDQ5H7M0
Protein RefseqThe length of the protein is 216 amino acids long.
The sequence is show below: MYQISTGFCVILSLFYGCSANFHQENSTVAVNCNPKTSGTITFMFQINSTGANCLLIAKQTEVKHNANSKKYSGHIDSNGNLNVKIKSFAKRTDSGLYVCATMNNNKLFFGEVTKIQGVPDPVTQGPKMIQTTLKPVVKTTMIKQCVCDKKGAKPMFKCETWIFTSLVGGCGLFLVLLIATIVYCNRLRTRRCPHHYKRQPRGPPAGHAKMPNSHF.

Reference

Reference1. Kasheta, M., Painter, C. A., Moore, F. E., Lobbardi, R., Bryll, A., Freiman, E., ... & Ceol, C. J. (2017). 1. Identification and characterization of T reg-like cells in zebrafish. Journal of Experimental Medicine, 214(12), 3519-3530.
2. Miyazawa, R., Matsuura, Y., Shibasaki, Y., Imamura, S., & Nakanishi, T. (2018). Cross-reactivity of monoclonal antibodies against CD4-1 and CD8α of ginbuna crucian carp with lymphocytes of zebrafish and other cyprinid species. Developmental & Comparative Immunology, 80, 15-23.
3. Ding, C., Fan, E., Wang, S., Guo, L., Li, J., & Liu, Q. (2017). A potential aquaculture vaccine vector: evaluation of a double-gene attenuated Listeria monocytogenes in zebrafish (Danio rerio). Aquaculture, 479, 311-320.
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Figure 1 qRT-PCR of selected genes in foxp3a:EGFP-positive thymocytes relative to bulk thymocytes. Relative CD4 and CD8 expression is also shown and represents zebrafish cd4-1 and cd8a genes. †, Expression of cd8a was below the limit of detection in foxp3a:EGFP-positive thymocytes.
Reference: Kasheta, M., Painter, C. A., Moore, F. E., Lobbardi, R., Bryll, A., Freiman, E., ... & Ceol, C. J. (2017). Identification and characterization of T reg-like cells in zebrafish. Journal of Experimental Medicine, 214(12), 3519-3530.

For Research Use Only | Not For Clinical Use.
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