Nicastrin
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Mouse Anti-Rhesus NCSTN Antibody (CBMOAB-52350FYA) (CAT#: CBMOAB-52350FYA)
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- Host species: Mouse
- Species Reactivity: Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: NCSTN
Mouse Anti-Chicken NCSTN Antibody (MO-AB-03057Y) (CAT#: MO-AB-03057Y)
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- Host species: Mouse
- Species Reactivity: Chicken (Gallus gallus)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, NCSTN
Mouse Anti-Chimpanzee NCSTN Antibody (MO-AB-13943W) (CAT#: MO-AB-13943W)
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- Host species: Mouse
- Species Reactivity: Chimpanzee (Pan troglodytes)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, NCSTN
Mouse Anti-Cattle NCSTN Antibody (MO-AB-16445R) (CAT#: MO-AB-16445R)
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- Host species: Mouse
- Species Reactivity: Cattle (Bos taurus)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, NCSTN
Mouse Anti-Dog NCSTN Antibody (MO-AB-31898W) (CAT#: MO-AB-31898W)
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- Host species: Mouse
- Species Reactivity: Dog (Canis lupus familiaris)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, NCSTN
Mouse Anti-Marmoset NCSTN Antibody (MO-AB-59825W) (CAT#: MO-AB-59825W)
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- Host species: Mouse
- Species Reactivity: Marmoset
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, NCSTN
Rabbit Anti-NCSTN Antibody (MO-DKB-01346W) (CAT#: MO-DKB-01346W)
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- Host species: Rabbit
- Species Reactivity: Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Dog (Canis lupus familiaris), Rhesus (Macaca mulatta)
- Application: WB, IF
- Protein: Nicastrin
- Size: 100µL
- Conjugate: NONE
- Alternative Names: Nicastrin, Anterior Pharynx-Defective 2, ATAG1874, KIAA0253
Mouse Anti-Zebrafish ncstn Antibody (CBMOAB-88530FYA) (CAT#: CBMOAB-88530FYA)
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- Host species: Mouse
- Species Reactivity: Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Nicastrin
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nicastrin, ncst
