Mouse Anti-Chicken NCSTN Antibody (MO-AB-03057Y)


Cat: MO-AB-03057Y
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityChicken (Gallus gallus)
CloneMO03057Y
SpecificityThis antibody binds to Chicken NCSTN.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer''s disease; however, the nature of the encoded protein''s role in Alzheimer''s disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Product OverviewThis product is a mouse antibody against NCSTN. It can be used for NCSTN detection in Western Blot and Enzyme-Linked Immunosorbent Assay.
Alternative NamesNicastrin; NCSTN
UniProt IDQ67BJ3
Protein RefseqThe length of the protein is 717 amino acids long. The sequence is show below: MGRAGGRRGMTAVVGSCWISLPAWCGPLPALLLALLVAGSCEGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLNWVLADGPHPPYMILLDGNLFNRKVMQQLKGTSRVSGLAVSVAKPSPPQGFSPGLKCPNDGFGVYSKDYGPQYAHCNRTVWNPVGSGLSYEDFDFPIFLLEDANETQVIKQCYQDHNVPTDGSGPEYPLCAMQLFSHMHAVTSTVTCMRRNSIQNTFSINPETVCDPLLDYNVWSTLHPINASEKVDPKKEFIMVATRIDSHSFFWNIAPGAESAVSSFVTHLAAAEALHKASDVHLLQRNIMFTFFQGETFDYIGSSRMVYDMEKDKFPLRLENIHSFVELNQVALRNGSILWMHTDPVSRLNATVEPQVKNLLDILSNSSVGANVTLQEVGFSQPLPPSSFQRFLRARHIPGVVLSDHQASFQNRYYQSMYDTPENIQMQYPEGLSPEETLEYVTDTAKSLAEVATVVARALYRLAGGANDTSAIQADPKTITQMLYGFLIKMNNSWFQSIIKPDLKGILGDEVPQHYVAVSSPVNTTYLVQYVLANLTGTVVNLTKEECLNPEKTPNAEKEMYDYAWVQGSLDPNSTSRVPYCVRSTVRLSKALSPAFELREWGSTEYSTWTESRWKEIRARIFLVASKELEIITLVVGIAILVLSLIATHFINAKADVLFSIPRDPGAVSY.
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For Research Use Only | Not For Clinical Use.
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