Mouse Anti-Frog Rad17 Antibody (MO-AB-06861H)


Cat: MO-AB-06861H
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFrog (Xenopus laevis)
CloneMO06861C
SpecificityThis antibody binds to Frog Rad17.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
Product OverviewThis product is a mouse antibody against Rad17. It can be used for Rad17 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesRFC-like DNA checkpoint protein Rad17; Rad17
UniProt IDQ7ZZU6
Protein RefseqThe length of the protein is 674 amino acids long.
The sequence is show below: MSKTSCRRKVNSAKITDWVEPSFEDFFGNTSKASSQTSGIVKRCAQTKNESSLENKQGKKRTNPFTKDHASDNNQHTFDYSQNDPWIDKYRPEIQAELAVHKKKIEEVEAWLKTHVEKRPQKQGGQILLLTGPPGCGKTATIQVLTKEMGIQVQEWINPLMQEFKQDLPEVFDRDTRFQPFTSQSQTSLFHDFLLRANKYNKLQMVGESLSTDRKIIVVDDMPNQFYRDPSALHDILRRFVKTGRCPLVFIISDSLSGESHQRRLFPKEIQEELVVNNISFNPVAPTTMTKVLTRIASTEANASGGKIIIPDKASLELICTGSSGDIRSAINSLQFSARQGSSLKNDSWSKSRGKASKSGKPSSKSKTKKEPRKGGENVEEVQAIGGKDASLFLFRALGKILYCKRDPVPDDTDVYRLPAHLSEYNRDLLLILPEAVVEKSHMNGDLFNLYLHQNYLEFFMDIDDVVRASEYLSSADVLSGDWNSRSTLSVYSSSVASRGIIHSNSARAFVNCQGGVGFKPLHKPQWLAINKKHQENCLAARSLFSTFCSTPLGLQTQVVPYLAMLTNPLRNPSQIAFIQDVGRLPLKRQFGRLKLEALTDKDSGLPDGESGEEDNLTEMQRERNDTANSMGDGKELLSSQGLESELPASQPQPVAAQAIMEDEELKIEEYDSD.
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For Research Use Only | Not For Clinical Use.
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