Rabbit Anti-GPX4 Antibody (AA 30-70)
Cat: MO-NAB-00372W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio) |
| Clone | NW0297 |
| Specificity | This antibody is binds to Human GPX4 and has cross reactivity with Mouse, Rat, Zebrafish. |
| Immunogen | Human glutathione peroxidase 4/GPX4 aa synthetic peptide within 30-70. |
| Epitope | The epitope is in the AA 30-70 of GPX4. |
| Format | Liquid or Lyophilized |
| Buffer | TBS, pH7.4, 1% BSA, 40% Glycerol. |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein A purified |
| Cellular Localization | Mitochondrion |
Application Information
| Application | WB, IHC, IHC-P |
| Application Notes | Western Blot: 1:500-1:2000 Immunohistochemistry-Paraffin: 1:50-1:200 |
Target
| Introduction | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. |
| Product Overview | This product is a Rabbit antibody against the AA 30-70 of the GPX4. It can be used for GPX4 detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin. |
| Alternative Names | Glutathione Peroxidase 4; Phospholipid Hydroperoxidase; EC 1.11.1.12; GSHPx-4; GPx-4; PHGPx; Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial; Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase) |
| Gene ID | 2879(Human); 625249(Mouse); 29328(Rat) |
| UniProt ID | P36969(Human); O70325(Mouse); P36970(Rat) |
See other products for " GPX4 "
| MO-AB-18189W | Mouse Anti-Chimpanzee GPX4 Antibody (MO-AB-18189W) |
| MO-AB-02216Y | Mouse Anti-Chicken GPX4 Antibody (MO-AB-02216Y) |
| CBMOAB-04658HCB | Mouse Anti-C. elegans GPX4 Antibody (CBMOAB-04658HCB) |
| MO-AB-04046H | Mouse Anti-Frog gpx4 Antibody (MO-AB-04046H) |
| CBMOAB-44072FYA | Mouse Anti-Rhesus GPX4 Antibody (CBMOAB-44072FYA) |
| MO-AB-37382W | Mouse Anti-Goat GPx4 Antibody (MO-AB-37382W) |
| CBMOAB-60124FYC | Mouse Anti-Rhesus GPX4 Antibody (CBMOAB-60124FYC) |
| MO-AB-13333R | Mouse Anti-Cattle GPX4 Antibody (MO-AB-13333R) |
| MO-AB-26106H | Mouse Anti-Rat Gpx4 Antibody (MO-AB-26106H) |
| MO-AB-07695W | Mouse Anti-Cat GPX4 Antibody (MO-AB-07695W) |
For Research Use Only | Not For Clinical Use.
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