Rabbit Anti-GPX4 Antibody (AA 30-70)

Cat: MO-NAB-00372W
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Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
SpecificityThis antibody is binds to Human GPX4 and has cross reactivity with Mouse, Rat, Zebrafish.
ImmunogenHuman glutathione peroxidase 4/GPX4 aa synthetic peptide within 30-70.
EpitopeThe epitope is in the AA 30-70 of GPX4.
FormatLiquid or Lyophilized
BufferTBS, pH7.4, 1% BSA, 40% Glycerol.
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein A purified
Cellular LocalizationMitochondrion

Application Information

ApplicationWB, IHC, IHC-P
Application NotesWestern Blot: 1:500-1:2000
Immunohistochemistry-Paraffin: 1:50-1:200


IntroductionThe protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Product OverviewThis product is a Rabbit antibody against the AA 30-70 of the GPX4. It can be used for GPX4 detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesGlutathione Peroxidase 4; Phospholipid Hydroperoxidase; EC; GSHPx-4; GPx-4; PHGPx; Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial; Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase)
Gene ID2879(Human); 625249(Mouse); 29328(Rat)
UniProt IDP36969(Human); O70325(Mouse); P36970(Rat)
For Research Use Only | Not For Clinical Use.
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