Rabbit Anti-IDH1 Antibody (MO-DKB-00658W)
Cat: MO-DKB-00658W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Rhesus (Macaca mulatta) |
| Immunogen | A recombinant protein containing sequences in the central region of human IDH1. |
| Epitope | The epitope is in the Center of IDH1. |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH 7, 20% Glycerol |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | Affinity purified |
| Cellular Localization | Cytoplasm, Peroxisome |
Application Information
| Application | WB, IHC, IHC-P, IP, KD, KO |
| Application Notes | Western Blot 1:1000-1:10000 Immunohistochemistry 1:1000-1:10000 Immunohistochemistry-Paraffin 1:100-1:1000 Immunoprecipitation 1:100-1:1000 |
Target
| Introduction | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
| Product Overview | This product is a Rabbit antibody against the Center of the IDH1. It can be used for IDH1 detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Knockdown Validated, Knockout Validated. |
| Alternative Names | Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic |
| Gene ID | 3417 |
| UniProt ID | O75874 |
See other products for " IDH1 "
| MO-AB-41844W | Mouse Anti-Guinea pig IDH1 Antibody (MO-AB-41844W) |
| MO-DKB-03942W | Goat Anti-IDH1 (Center) Antibody (Cat MO-DKB-03942W) |
| MOFAB-522W | Mouse Anti-Zebrafish idh1 Antibody (MOFAB-522W) |
| MO-AB-15701Y | Mouse Anti-Sheep IDH1 Antibody (MO-AB-15701Y) |
| MO-AB-24006W | Mouse Anti-Chimpanzee IDH1 Antibody (MO-AB-24006W) |
| MO-AB-06561Y | Mouse Anti-O. anatinus IDH1 Antibody (MO-AB-06561Y) |
| MO-AB-09136W | Mouse Anti-Cat IDH1 Antibody (MO-AB-09136W) |
| MO-NAB-00514W | Goat Anti-IDH1 Antibody |
| MO-AB-38586W | Mouse Anti-Gorilla IDH1 Antibody (MO-AB-38586W) |
| MO-AB-31761H | Mouse Anti-Soybean IDH1 Antibody (MO-AB-31761H) |
For Research Use Only | Not For Clinical Use.
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