Mouse Anti-O. anatinus IDH1 Antibody (MO-AB-06561Y)
Cat: MO-AB-06561Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | O. anatinus (Ornithorhynchus anatinus) |
Clone | MO06561Y |
Specificity | This antibody binds to O. anatinus IDH1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Peroxisome; Cytosol; Mitochondrion |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
Product Overview | This product is a mouse antibody against IDH1. It can be used for IDH1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Isocitrate dehydrogenase [NADP]; EC 1.1.1.42; IDH1 |
UniProt ID | F7AUG7 |
Protein Refseq | The length of the protein is 415 amino acids long. The sequence is show below: MSSKICGGSVVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIENRDATNDKVTSEAAEAIKKYNVGIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPRPGKVEMVYTPQDGGKAVTYLVHNFEAGGGVAMGMYNLDQSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKQYRSKFEAKKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHFRMHQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSTFATTLEDVCVETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLASQAKL. |
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For Research Use Only | Not For Clinical Use.
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