Mouse Anti-IDH1 Antibody
Cat: MO-NAB-00344W
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Human (Homo sapiens), Zebrafish (Danio rerio) |
| Clone | NW0272 |
| Specificity | This antibody is binds to Human IDH1 and has cross reactivity with Zebrafish. |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH7.4, 0.2% BSA, 40% Glycerol. |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein A affinity purified. |
| Cellular Localization | Cytoplasm |
Application Information
| Application | WB, IHC-P |
| Application Notes | Western Blot: 1:1000 Immunohistochemistry-Paraffin: 1:100-1:200 |
Target
| Introduction | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| Product Overview | This product is a Mouse antibody against the IDH1. It can be used for IDH1 detection in Western Blot, Immunohistochemistry-Paraffin. |
| Alternative Names | Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic |
| Gene ID | 3417(Human); 15926(Mouse); 24479(Rat) |
| UniProt ID | O75874(Human); O88844(Mouse); P41562(Rat) |
See other products for " IDH1 "
| MO-AB-08433Y | Mouse Anti-Rabbit IDH1 Antibody (MO-AB-08433Y) |
| MO-NAB-00514W | Goat Anti-IDH1 Antibody |
| MO-AB-31214W | Mouse Anti-Dog IDH1 Antibody (MO-AB-31214W) |
| MO-AB-24006W | Mouse Anti-Chimpanzee IDH1 Antibody (MO-AB-24006W) |
| CBMOAB-80247FYA | Mouse Anti-Zebrafish idh1 Antibody (CBMOAB-80247FYA) |
| MO-AB-15701Y | Mouse Anti-Sheep IDH1 Antibody (MO-AB-15701Y) |
| CBMOAB-35151FYC | Mouse Anti-Arabidopsis IDH1 Antibody (CBMOAB-35151FYC) |
| MO-DKB-03942W | Goat Anti-IDH1 (Center) Antibody (Cat MO-DKB-03942W) |
| CBMOAB-01822CR | Mouse Anti-Yeast IDH1 Antibody (CBMOAB-01822CR) |
| MO-DKB-00658W | Rabbit Anti-IDH1 Antibody (MO-DKB-00658W) |
For Research Use Only | Not For Clinical Use.
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