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Rabbit Anti-map1lc3b Antibody (MOFAB-028W)


Cat: MOFAB-028W
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  • Product Details

Specifications

Host speciesRabbit
Species ReactivityZebrafish
ImmunogenPeptides from zebrafish LC3b sequences
FormatLiquid
BufferPBS, pH 7.2, 50% glycerol
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
PurificationAntigen Affinity Purified

Application Information

ApplicationELISA, WB
Application NotesWB: 1:1000-2000

IP: 3ug/Sample

IF: 1:100-200
The optimal dilution should be determined by the end user.

Target

IntroductionIt is observed enhanced LC3B and other autophagy-related molecules by inducing oxidative stress in OC cells using ROS-generating pro-oxidant molecules. Enhanced LC3B fails to induce autophagosome formation, possibly due to reduced ULK1 complexes. ROS-induced enhanced LC3B also increased apoptosis. Furthermore, LC3B inhibits cell adhesion molecules/mesenchymal markers, leading to anoikis. Furthermore, in vitro studies showed that ROS-dependent enhanced LC3B reduced tumor growth. Similar effects were observed with primary cells from patients. Here, we demonstrate the unique role of LC3B in in vitro/in vivo/ex vivo induction of anoikis.
Product OverviewThis product is a Rabbit antibody against the map1lc3b. It can be used for map1lc3b detection in ELISA, Western Blot.
Alternative Namesmap1lc3b; LC3b; Zebrafish LC3b
For Research Use Only | Not For Clinical Use.

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