Anti-BEST1 Antibody (Cat MORAB-027F), Mouse IgG
Cat: MORAB-027F
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Chicken (Gallus gallus) |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH 7.4 |
| Regulatory Status | For Research Use Only |
| Shipping | Gel Pack |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 95% was determined by SDS-PAEG |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | IA |
| Application Notes | The optimal dilution should be determined by the end user. |
Target
| Introduction | Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other monovalent anions across cellular membranes in response to intracellular calcium (Ca(2+)) levels. Mutations in bestrophin 1 (BEST1) cause certain eye diseases. Here we present X-ray structures of chicken BEST1-Fab complexes, at 2.85 Å resolution, with permeant anions and Ca(2+). Representing, to our knowledge, the first structure of a CaCC, the eukaryotic BEST1 channel, which recapitulates CaCC function in liposomes, is formed from a pentameric assembly of subunits. Ca(2+) binds to the channel's large cytosolic region. A single ion pore, approximately 95 Å in length, is located along the central axis and contains at least 15 binding sites for anions. A hydrophobic neck within the pore probably forms the gate. Phenylalanine residues within it may coordinate permeating anions via anion-π interactions. Conformational changes observed near the 'Ca(2+) clasp' hint at the mechanism of Ca(2+)-dependent gating. Disease-causing mutations are prevalent within the gating apparatus. |
| Alternative Names | Best1 bestrophin-1, BEST1 |
| UniProt ID | E1C3A0 |
See other products for " best1 "
| CBMOAB-67627FYA | Mouse Anti-Zebrafish best1 Antibody (CBMOAB-67627FYA) |
| CBMOAB-02375FYA | Mouse Anti-D. melanogaster Best1 Antibody (CBMOAB-02375FYA) |
| CBMOAB-00900HCB | Mouse Anti-C. elegans BEST1 Antibody (CBMOAB-00900HCB) |
| MO-AB-01288W | Mouse Anti-Rhesus BEST1 Antibody (MO-AB-01288W) |
| MO-AB-08058R | Mouse Anti-Cattle BEST1 Antibody (MO-AB-08058R) |
| MO-AB-24121R | Mouse Anti-Pig BEST1 Antibody (MO-AB-24121R) |
| MO-AB-51847W | Mouse Anti-Marmoset BEST1 Antibody (MO-AB-51847W) |
| MO-AB-29237W | Mouse Anti-Dog BEST1 Antibody (MO-AB-29237W) |
For Research Use Only | Not For Clinical Use.
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