Sheep Anti-NR3C1 Antibody (MOFAB-122W)


Cat: MOFAB-122W
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Specifications

Host speciesSheep
Species ReactivityHuman, Monkey
SpecificityThe antibody reacts specifically with monkey and human glucocorticoid receptors.
ImmunogenA peptide consisting of amino acids 150-175 of the squirrel monkey glucocorticoid receptor conjugated to diphtheria toxoid. The sequence is identical in the human glucocorticoid receptor except for 2 amino acids (underlined): N-terminus - APKEKEFPKTHSDVSSEQ-QNLKGQTG-NH2 - C-terminus.
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.

Application Information

ApplicationWB
Application NotesWB:1:500-1:1000
The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Product OverviewThe NR3C1 antibody is used as Hormones and Serum Protein Antibodies.
Alternative NamesNuclear Receptor Subfamily 3 Group C Member 1; Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor); Glucocorticoid Receptor; GRL; GR; Nuclear Receptor Subfamily 3, Group C, Member 1
Gene ID2908
UniProt IDP04150
For Research Use Only | Not For Clinical Use.

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